The Natural Collection

Princeton BioMolecular Research  intensively explores a space of natural and semi-natural scaffolds as an important libraries development strategy. When designing the synthetic routes for new series, we maintain a “genetic originality” of the compounds by retaining their unique core scaffolds and applying focused modifications of side chains.

1000 natural compounds available.
2000 seminatural compounds available.

We offer the following:

1. Structural modification of natural products available in the collection Princeton BioMolecular Research Inc.
2. Chemical modification of natural products from the customer suggestions.
3. Synthesis of isosteric analoges the natural product, and compound library on its base.

Historically, many marketed drugs were derived from other known drugs or natural products [1-14].

1. K.C. Nicolaou, Jason S. Chen, Stephen M. Dalby //From nature to the laboratory and into the clinic Bioorganic & Medicinal Chemistry, Volume 17, Issue 6, 15 March 2009, Pages 2290-2303
2. Bhuwan B. Mishra, Vinod K. Tiwari/Natural products: An evolving role in future drug discovery European Journal of Medicinal Chemistry, Volume 46, Issue 10, October 2011, Pages 4769-4807
3. Gemma L Thomas, Charles W Johannes/Natural product-like synthetic libraries /cle/ Current Opinion in Chemical Biology, Volume 15, Issue 4, August 2011, Pages 516-522
4. Matthew E Welsch, Scott A Snyder, Brent R Stockwell /Privileged scaffolds for library design and drug discovery /Current Opinion in Chemical Biology, Volume 14, Issue 3, June 2010, Pages 347-361
5. Ulrich Abel, Corinna Koch, Michael Speitling, Friedrich G Hansske //Modern methods to produce natural-product libraries /Current Opinion in Chemical Biology, Volume 6, Issue 4, 1 August 2002, Pages 453-458
6. John Nielsen //Combinatorial synthesis of natural products /Current Opinion in Chemical Biology, Volume 6, Issue 3, 1 June 2002, Pages 297-305
7. Alan Harvey// Strategies for discovering drugs from previously unexplored natural products Drug Discovery Today, Volume 5, Issue 7, 1 July 2000, Pages 294-300
8. Kin S. Lam //New aspects of natural products in drug discovery /Trends in Microbiology, Volume 15, Issue 6, June 2007, Pages 279-289
9. Alihussein N. Dohadwalla// Natural product pharmacology: strategies in search of leads for new drug designs /Trends in Pharmacological Sciences, Volume 6, 1985, Page 49
10. S Mbua Ngale Efange /Chapter 5 Natural products: a continuing source of inspiration for the medicinal chemist /Advances in Phytomedicine, Volume 1, 2002, Pages 61-69
11. Marcy J. Balunas, A. Douglas Kinghorn /Drug discovery from medicinal plants Life Sciences, Volume 78, Issue 5, 22 December 2005, Pages 431-441
12. Armen M Boldi .Libraries from natural product-like scaffolds Review Article Current Opinion in Chemical Biology, Volume 8, Issue 3, June 2004, Pages 281-286
13. Kai U. Bindseil, Jasmin Jakupovic, Dietmar Wolf, Jacques Lavayre, Jean Leboul, Didier van der Pyl //Pure compound libraries; a new perspective for natural product based drug discovery //Drug Discovery Today, Volume 6, Issue 16, 15 August 2001, Pages 840-847
14. A Ganesan //The impact of natural products upon modern drug discovery Current Opinion in Chemical Biology, Volume 12, Issue 3, June 2008, Pages 306-317

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