Focused Libraries

We offer a wide variety of unique Focused Library sets targeting Kinases, GPCRs and some other enzymes. There are also Focused Libraries targeting specific sub-families of biological targets. Thus our Kinase Library contains over a dozen subsets of compounds with specific kinase activity and our GPCR Library similarly has ten subsets of compounds.

To assemble a set of compounds with particular biological activity we carefully selected known pharmacophores and novel inhibitors from the recent patents, literature and available databases. This information was further filtered with our proprietary computational methods, as well as PSA, ClogP, Tanimoto similarity and other predictions. Each set contains between 300 and 1000 compounds in amounts from 1mg to 5mg in the clients desired form; vials, plates, dry form, or dissolved in DMSO. General purity levels are 90%-95%.

Lead-time for delivery can be short as two weeks, depending on the number of samples that have been selected.

Kinase Sets	Miscellaneous Enzyme Sets
PIK3CG CSF1R EGFR EPHA2 EPHA3 EPHA5 ERBB4 FGFR1 FGFR2 IGF1R INSR KIT MET RET TIE2 VEGFR2 ABL1 ABL1_T315I CSK FES FYN HCK ITK JAK2 JAK3 LCK PTK2 PTK2B SRC SYK TNK2 WEE1 ZAP70 AKT2 AURKA BRAF CHEK1 CHEK2 CSNK1G2 CSNK1G3 CSNK2A1 DAPK1 DAPK2 DAPK3 LOK MAPKAPK2 MARK1 MKNK2 MST1 NEK2 PAK1 PAK4 PAK6 PAK7/PAK5 PDPK1 PIM1 PIM2 PRKR ROCK1 RPS6KA1 SLK SRPK1 STK16 PRKCQ CAMK2B PLK1 PLK4 CDK2 CDK5 CDK7 ERK2 ERK3 JNK1 JNK2 JNK3 p38-alpha p38-delta p38-gamma MAP3K5 TAK1 GSK3B TGFBR1 CLK1 CLK3 MEK1 MEK2	Dihydrofolate reductase HMG-CoA reductase vitamin D receptor Phospholipase A2 PPAR-g (Peroxisome Proliferator-Activated Receptor) Thyroid hormone receptor beta Liver X receptor beta Dihydroorotate dehydrogenase Leukotriene A4 hydrolase Beta-lactamase Estrogen receptor beta Liver X receptor alpha Farnesoid X receptor Glucocorticoid receptor Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor delta Mineralocorticoid receptor HIV-protease Thyroid hormone receptor alpha Retinoic acid receptor alpha Retinoic acid receptor gamma Androgen receptor Acetylcholine esterase Retinoic acid receptor beta Retinoid X receptor alpha Retinoid X receptor beta Metabotropic glutamate receptor 1 (mGluR1) Metabotropic glutamate receptor3 (mGluR3) Metabotropic glutamate receptor 7 (mGluR7) NMDA receptor Adrenaline receptor beta 2 Endothelial growth factor receptor kinase (EGFR) Orotidine-5'-monophosphate decarboxylase
GPCR Sets	Channel Blocker Sets
Endothelin Receptor Antagonists GHS1a Antagonists NK2 Antagonists 5HT1 Antagonists 5HT2 Antagonists 5HT3 Antagonists 5HT4 Antagonists 5HT1 Agonists 5HT3 Agonists 5HT4 Agonists Dopamine Antagonists CCR2 Antagonists CCR5 Antagonists CRF1 Antagonists Sst Antagonists Angiotensin II Receptor Antagonists Bradykinin BK2 Antagonist Histamine H3 Antagonist	Ca Channel Blocker Na Channel Blocker K Channel Blocker Ion Channel Blocker

Focused Libraries

Discovery Outsource